Goldstein [14] and Mercimek-Mahmutoglu [24] reported that Gnao1-related movement disorder was associated with to the presynaptic role of Gαo (Gnao1-encoded G protein) in regulating the release of neurotransmitters including the dopamine, epinephrine, noradrenaline and 5-hydroxytryptamine, etc.. The gene discussed is GNAO1; the disease is movement disorder.