CFLAR and neoplasm: It regulates apoptosis, cell proliferation, and differentiation as well as inflammation, angiogenesis, and tumor migration through transcription of growth factors/signaling molecules (IL-6, TGFb, TNFa, IGF-1, SDF-1, HGF), cell-adhesion molecules (VLA-4, VLA-5, ICAM), angiogenesis factors (VEGEFs, angioprotein-1, MCP-1), and anti-apoptotic enzymes (Bcl-2, Bcl-XL, cIAP, XIAP, FLIP, STAT-3, and Mcl-1) [11–14].