SIRT1 and metabolic dysfunction-associated steatotic liver disease: A recent study illustrated that the SIRT1 activator E1231, a piperazine 1,4-diamide compound, alleviated NAFLD induced in C57BL/6 J mice fed a high-fat and high-cholesterol diet and improved liver injury by regulating the SIRT1-AMPK alpha pathway, suggesting that this compound is a promising candidate compound for NAFLD treatment [141].