ADIPOQ and metabolic dysfunction-associated steatotic liver disease: However, downstream signaling events involving transcription factor-regulating genes involved in lipid synthesis and the endoplasmic reticulum (ER) stress response are present in both NAFLD and ALD in the context of fatty acid oxidation mediated by AMP-activated protein kinase (AMPK), adiponectin, and peroxisome proliferator-activated receptors (PPARs) [40].