Meanwhile, since BHG was enriched in cancer driver and progression-related pathways (Additional file  2: Table S8), we constructed and visualized the regulatory network of BHGs in the 4 driver pathways (PI3K/AKT Signaling in Cancer, MAPK family signaling cascades, Diseases of signal transduction by growth factor receptors and Signalings by VEGF) based on gene expression data and clinical information (tumor/normal) using CBNplot (Fig. 8C). The gene discussed is VEGFA; the disease is cancer.