SERPINE1 and neoplasm: The ek1-ek4 sharing the similar expression pattern were distributed in the early stage of the trajectory, and their hallmark genes were correlated with the early features of tumor EMT (such as cell adhesion: GJA1 [49], stemness: DKK3 [50], CD276 [51], and ECM regulation: PLAU, PDPN and SERPINE1 [52–54]), which suggested the roles of Community 1 in early EMT.