As the marker of exhaustive CD8 T cells, HAVCR2 regulates EMT by crosstalking Akt/GSK-3β/Snail signaling pathway [59] with SMAD7/SMAD2/ SNAIL1 Axis [60], implicating the dual role of Community 1-related immune genes in EMT and tumor immune. This evidence concerns the gene SMAD2 and neoplasm.