EGFR and head and neck squamous cell carcinoma: Actually, the HPV positive patients in TCGA HNSCC cohorts showed the the higher IWHMB of 3 EGFR pathways than those of HPV negative patients (Additional file 1: Fig. S2B) (p < 0.2, the mean difference > 0), which implied that EGFR pathway played differential roles in HPV positive and negative patients.