Among the 22 immune cells scored by CIBERSORT, MEC1 of Community 1 exhibited the significantly positive correlation (r > 2, p < 0.05) with 3 immune cells (Macrophages M0, Macrophages M2 and T cells CD4 memory resting) and significantly negative correlation (r < -2, p < 0.05) with 4 immune cells (T cells CD4 memory activated, T cells CD8, Plasma cells and T cells follicular helper) in at least 3 HNSCC cohorts (Fig. 5J). The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.