When the TCGA HNSCC cohort was divided into HPV positive and negative groups, the high IWHMB of TNFA_SIGNALING_VIA_NFKB and INFLAMMATORY_RESPONSEHGS implicated a worse prognosis in HPV positive group (log rank:p < 0.05, HR > 1), while the high IWHMB of TGF_BETA_SIGNALING and APOPTOSIS suggested a worse prognosis in the HPV negative group (log rank:p < 0.05, HR > 1) (Fig. 2D). This evidence concerns the gene NFKB1 and head and neck squamous cell carcinoma.