EGFR and head and neck squamous cell carcinoma: In the TCGA HNSCC cohort, REACTOME SIGNALING BY EGFR and EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY showed the high IWHMB in metastasis group (Additional file 1: Fig. S2D) (TCGA HNSCC: p < 0.3, the mean difference > 0).