POSTN and neoplasm: Upregulation of the CAF-induced pre-metastatic niche (PMN) marker POSTN (cluster 11) [69], chemotaxis and vasculature (clusters 12 and 25) as well as higher deconvolution weights of endothelial cells and macrophages in the PC1-high regions are evidence for a tumour promoting role of CAFs at the leading edge of tumours [70].