A member of the miR-183 cluster (miR-183, miR-182, miR-96), miR-182 can promote cancer invasion by linking rearranged during transfection (RET) oncogene-activated nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) to loss of the hes family bHLH transcription factor 1 (HES1)/notch receptor 1 (NOTCH1) regulatory circuit [48]. The gene discussed is HES1; the disease is cancer.