The miR-10a inhibits proliferation and migration and promotes apoptosis of breast cancer cells via phosphoinositide/Akt/mammalian target of rapamycin (mTOR) signaling, and the mitochondrial apoptotic pathway [44], and miR-10a is downregulated by DNA methylation and functions as a tumor suppressor in gastric cancer cells [45]. This evidence concerns the gene AKT1 and breast carcinoma.