Based on clinical and experimental study data on this new treatment strategy, the authors can say that dual blockade provides improvement in disease symptoms in a short time and a better anti-inflammatory response is obtained in the regulation of inflammatory process-related genes compared to treatments targeting only IL-17A.12, 13, 14, 15 As a result of evaluating this information, it seems possible to say that the IL-17F gene locus plays a role as a central cytokine in the immunopathogenesis of psoriasis. The gene discussed is IL17F; the disease is psoriasis.