AKT1 and neoplasm: Anlotinib can inhibit the phosphorylation expression of related proteins and induce apoptosis of tumor cells by acting on Fibroblast Growth Factor Receptor (FGFR), Platelet-Derived Growth Factor Receptor (PDGFR-β) and downstream Extracellular Regulated protein Kinase (AKT/ERK) signaling pathway, in a dose-dependent manner.11, 12, 13 The formation of abnormal blood vessels in the tumor microenvironment is closely related to tumor genesis and development.