HIF-1α can enable hypopharyngeal cancer tumor cells to tolerate the hypoxia microenvironment and can improve the ability of tumor metastasis by regulating local glucose metabolism, angiogenesis tumor invasion, and other activities.26, 27, 28 However, whether anlotinib could regulate HIF-1α expression remains unclear. The gene discussed is HIF1A; the disease is hypopharynx cancer.