CALR and neoplasm: It has been reported that ER stress loading on cancer cells enhances anti-tumor immunity by generating ‘find-me’ and ‘eat-me’ signals such as adenosine triphosphate (ATP) release and increased membrane expression of calreticulin via the activation of protein kinase ribonucleic acid-like endoplasmic reticulum kinase endoplasmic reticulum kinase [20].