In both the CT26 and LLC models, the groups administered with 30 mg/kg MHY1485 alone showed no tumor growth suppression in comparison with the DMSO group; by contrast, the group administered with 30 mg/kg MHY1485 with radiation showed significant tumor growth suppression as compared to the radiation + DMSO group (Fig. 3 and Supplementary Fig. 3). The gene discussed is DDX53; the disease is neoplasm.