MTAP and colorectal carcinoma: APOBEC enzyme trinucleotide signature was more frequently observed among MTAP-loss CRC (7.3% vs 1.3%, P = .054) and PDAC (16.7% vs 5.6%, P = .044), compared with MTAP-intact tumors; while UV radiation signature was more frequently observed among homozygous MTAP-loss CRC compared with MTAP-intact tumors (4.9% vs 0.2%, P = .015).