MTAP-loss occurred in 21.6% (3401/12 319 tumors) of PDAC, 15.3% (785/4352 tumors) of IHCC, 8.7% (589/6143 tumors) of GEAC, 2.4% (32/1306 tumors) of HCC, and 1.1% (396/35 537 tumors) of CRC (Fig. 2A; Supplementary Fig. S1). The gene discussed is MTAP; the disease is hepatocellular carcinoma.