MTAP-loss CRC was associated with a lower frequency of alterations in APC (48% vs 79%, P < .0001) and CTNNB1 (1.5% vs 4.3%, P = .014), but a higher frequency of alterations in STK11 (3.3% vs 0.7%, P < .0001) and KEAP1 (1.3% vs 0.4%, P = .067) compared with MTAP-intact CRC. Here, APC is linked to colorectal carcinoma.