Patients presenting with cryptococcal meningitis in Botswana typically had a CD4 count <50 cells/μL, highlighting that a hard-to-reach population, with an overrepresentation of working age males, remains at risk of cryptococcal meningitis usually due to late diagnosis or cycling out of treatment services due to the failure of services to effectively engage and retain this group. Here, CD4 is linked to Cryptococcal meningitis.