The beta and their respective 95% CI, calculated using IVW, are as follows: T2DM and sd LDL particles [-0.028, (-0.084;0.029), p = 0.338]; T2DM and sd LDL cholesterol [-0.040, (-0.102;0.022), p = 0.205]; Fasting glucose and sd LDL particles [0.009, (-0.119;0.137), p = 0.892]; Fasting glucose and sd LDL cholesterol [-0.006, (-0.136;0.124), p = 0.927]; Fasting insulin and sd LDL particles [0.180, (-0.089;0.449), p = 0.189]; Fasting insulin and sd LDL cholesterol [0.042, (-0.212;0.296), p = 0.747]. The gene discussed is INS; the disease is type 2 diabetes mellitus.