These Boolean paths contained molecules present in the following canonical pathways: 1) Acute phase response signaling; 2) Huntington’s disease signaling; 3) Neuroinflammation signaling; 4) Role of JAK1 and JAK3 in gamma-c cytokine signaling; 5) Role of macrophages, fibroblast, and endothelial cells in rheumatoid arthritis; 6) Role of pattern recognition receptors in recognition of bacteria and viruses; 7) Role of tissue factor in cancer; and 8) T helper cell differentiation. This evidence concerns the gene JAK1 and rheumatoid arthritis.