Intriguingly, although VEGFR2 inhibition induced vessel relaxation by increasing interbranching distances (Figure 9E) and decreased individual and total tumor burden (Figure 8, E and F), interventions by Reparixin or MMP14i were more efficacious in suppressing vascularization (Figure 9, A–D and Supplemental Figure 8F) and reducing tumor burden (Figure 8, D–G) in a PMN-dominant colitis-associated CRC model. Here, KDR is linked to colitis.