The Cancer Genome Atlas (TCGA) database mining of 592 colorectal adenocarcinoma patient cohort (COAD, Pan-Cancer Atlas/cBioPortal) (28) consistently linked high expression of EC PECAM-1 and PMN/TAN S100A8 with poor prognosis and disease outcomes (Supplemental Figure 5C). This evidence concerns the gene S100A8 and colorectal adenocarcinoma.