MMP14 and fibroblastic neoplasm: Consistent with Collagen I being a primary substrate of MMP14, tissue deposition of Collagen I (50) but not Laminin-1 (51) (another MMP14 substrate) was significantly enhanced with MMP14 inhibition, resulting in fibrous tumor morphology and reduced vascularization (Figure 9, F–K and Supplemental Figure 8F).