Circulating PMNs in advanced CRC–bearing mice displayed gene signature previously associated with PMN-MDSCs (14) (Ltf, Npg, Camp, and Lcn2), whereas matched TANs displayed more proteolytic (Adam8, Ctsb, and Mmp12) and secretory gene signatures (Ccl4, Cxcl1, and Il1b, Supplemental Figure 3, A and B). This evidence concerns the gene CTSB and colorectal carcinoma.