Imaging and flow cytometry analyses (gating strategy shown in Supplemental Figure 6, A–D) revealed overall MMP14 expression to be highly induced in TANs compared with circulating PMNs, with MMP14hi TAN subset detected in both early and advanced tumors, as well as in tumor-adjacent regions (Figure 6C and Supplemental Figure 6, E–G). The gene discussed is MMP14; the disease is neoplasm.