Interestingly, although, as expected, VEGFR2 inhibition led to normalization of tumor vasculature and overall reduction in vascular density, we showed that such treatment was less effective in inducing tumor regression compared with MMP14i, which more robustly and reproducibly disrupted tumor vasculature and suppressed tumor growth in both AOM/DSS and PDX models. Here, KDR is linked to infectious otitis media.