Complementarily, reverse-transcription quantitative PCR (RT-qPCR) analyses on UC and CRC tissues similarly revealed robust induction of MMP14, SPP1, and VEGFA (Figure 6E), but not of the angiogenic receptors VEGFR1 and VEGFR2, or TGF1B (Supplemental Figure 7D) in grade 3 CRC. The gene discussed is SPP1; the disease is colorectal carcinoma.