Consistently, row-scaled expression analyses with K-means clustering revealed previously established TAN-associated gelatinase/tertiary granule genes (Mmps12/13, Adam8) to be enriched in advanced CRC tumors compared with secondary granule genes (Ltf, Mmps8/25, Adams10/15) associated with blood PMNs (10, 14) (Supplemental Figure 3A). The gene discussed is ADAM8; the disease is colorectal carcinoma.