S100A9 and colorectal carcinoma: Further dual IHC staining for S100A9 and MMP14 followed by digital color deconvolution confirmed an abundant presence of high MMP14-expressing TANs in all 4 patients (Figure 11E and Supplemental Figure 11B), confirming TANs as a major MMP14 source in CRC and establishing the relevance of targeting MMP14 in human disease.