Consistent with previous reports, MMP14 and OPN expression was also detected on tumor macrophages and EpCAM+ tumor cells (38–41), however, at 2- to 3-fold lower levels compared with TANs (Supplemental Figure 6, K, L, O, and P), indicating TANs as a major source of MMP14 and OPN in the CRC tumor niche. Here, SPP1 is linked to colorectal carcinoma.