A recent study carried out by Eltimamy et al. (2022) showed that the ethanolic T. chebula extract has anti-diabetic, anti-lipidemic, hepatoprotective and renoprotective effects against DM and this is probably attributed to the promotion of insulin release beside the insulin-like action of its phyto-constituents (Abu-Odeh and Talib 2021). This evidence concerns the gene INS and diabetes mellitus.