M6A-modified circNSUN2 binds YTHDC1 (YTH domain-containing protein 1) and promotes its exit from the nucleus, further binding IGF2BP2 (lnsulin-like growth factor 2 mRNA-binding protein 2), which stabilizes HMGA2 (high mobility group AT-hook 2) mRNA, thus promoting colorectal cancer liver metastasis (Chen et al. 2019). The gene discussed is HMGA2; the disease is colorectal cancer.