SERPINB3 and non-small cell lung carcinoma: qRT-PCR results illustrated that compared with traditional markers such as CEA, SCC, and Cyfra21-1 (Fig. 3b–d), circBRIP1 expression levels were not only significantly higher than those of BPD and healthy individuals, but could also significantly distinguish NSCLC patients from BPD (P < 0.001) and healthy individuals (P < 0.001) (Fig. 3a).