In addition, bioinformatic analysis of the circRNA–miRNA–mRNA regulatory axis of circBRIP1 in NSCLC and the downstream RBP showed that among these predictable targets, hsa-miR-526b-3p, a miR that inhibits PD-L1, can inhibit NSCLC development and regulate cell cycle, migration, invasion, apoptosis, tumor chemosensitivity and host antitumor immune response, and its ectopic expression may improve the prognosis of NSCLC patients (Shadbad et al. 2022). This evidence concerns the gene CD274 and non-small cell lung carcinoma.