SHH and medulloblastoma: Genetic mutations affecting genes associated with Shh signaling are responsible for the developmental diseases such as holoprosencephaly or medulloblastoma (Wolter et al. 1997; Reifenberger et al. 1998; Traiffort et al. 2004; Ruat et al. 2015; Andreu-Cervera et al. 2021).