TNF and blood coagulation disease: CRS is a systemic inflammatory response caused by CAR-T cell activation and proliferation and significant concomitant elevations of multiple serum cytokines [20], with the most pronounced peaks being IL-6, IL-1, interferon (IFN)-γ, and tumor necrosis factor-α (TNF-α), followed by IL-8, IL-10, monocyte chemotactic protein-1, and granulocyte-macrophage colony-stimulating factor [18, 21–23], leading to capillary leakage, elevated transaminases, and coagulation disorders [24–26].