Vamp3 S48 is predicted to be highly functional (functional score = 0.750) (Ochoa et al., 2020), its phosphorylation correlates with glucose uptake in insulin-stimulated and/or exercised human skeletal muscle (Needham et al., 2022), and Vamp3 overexpression rescues GLUT4 translocation in insulin resistance (Schwenk et al., 2012), suggesting that this site may represent a genetically variable control point of GLUT4 trafficking. The gene discussed is INS; the disease is Insulin resistance.