INS and Insulin resistance: This is consistent with our previous findings that glycolytic enzyme abundance was strongly associated with ex vivo insulin-stimulated glucose uptake in muscle from inbred mice (Nelson et al., 2022), that the insulin resistance-reversing small molecule thiostrepton enhances glycolytic capacity (Masson et al., 2023), and that decreasing glycolytic flux caused insulin resistance in vitro (Trefely et al., 2015).