Figure 1B demonstrated a notable up-regulation of SPP1 in LUAD and LUSC tissues when compared with normal tissues (all p < 0.001). A similar analysis was conducted on the GSE101929, GSE19188, and GSE116959 datasets. The analysis of SPP1 expression in NSCLC, in comparison to normal tissues, also revealed a significant over-expression of SPP1 (all p < 0.01; Figure 1C). Hence, it could be concluded that SPP1 exhibited elevated levels of expression in NSCLC. The gene discussed is SPP1; the disease is non-small cell lung carcinoma.