The abundant anti-inflammatory macrophages M2 infiltration is not conducive to the anti-tumor function of other immune cells, thus M1 macrophage inducers may be more beneficial for cancer treatment in high-risk patients [79], meanwhile based on the significant positive correlation, the overexpression of ABCD7 and FLRT3 could enhance the NK cell activation for tumor cell killing. The gene discussed is FLRT3; the disease is cancer.