After that, the phosphorylated SHC activated the mitogen-activated protein kinase (MAPK) pathways for cell cycle regulation [16] and the IRS activated the phosphatidylinositol 3-kinase (PI3K)/AKT for RNA processing, protein translocation, cell proliferation, autophagy and apoptosis in malignancy [17] and IGF-I induced the anti-inflammatory cytokines interleukin (IL)-10 for cancer progression [18]. This evidence concerns the gene PIK3CA and cancer.