The expression levels of these 16 genes (ASPH, NINJ1, SNAI1, UBTD1, MAP3K6, CDKN2A, E2F1, HDAC4, PLA2R1, PRKCD, WWP1, ID4, NEK1, P3H1, NDRG1, SORBS2) in tumor tissue and normal tissue in the TCGA-THCA cohort were displayed by heat map (Figure 3F). This evidence concerns the gene WWP1 and neoplasm.