C3 and Parkinson disease: Similarly to familial L2-PD, whereas CTL astrocytes maintained a large and flat morphology with low GFAP signal, ID-PD–derived astrocytes over the 14-day time point displayed a hypertrophic and ramified morphology (Figure 4, A and B; P < 0.001), overexpressed GFAP and C3 at protein levels (Figure 4, C and D; P < 0.01 and P < 0.001), and upregulated inflammatory-related genes (Supplemental Figure 4C; P < 0.05 and P < 0.001), comparable with CTL astrocytes stimulated with cytokines.