In addition to anti-nuclear antibodies (ANA), we detected anti-dsDNA antibodies, an autoantibody characteristic of lupus nephritis (1–3), in the serum of both HOIL-1LΔRING1/ΔRING1 and HOIL-1LΔRING1/+ mice, and the titer appeared to be related to the number of HOIL-1L ∆RING1 alleles (Figure 3, A and B). The gene discussed is BTG3; the disease is lupus nephritis.