TNIP1 and systemic lupus erythematosus: It is noteworthy, however, that no overt female predominance of SLE-like symptoms was reported in mice expressing the ABIN1 mutant lacking linear ubiquitin-binding activity (17, 19), although loss of linear binding of ABIN1 augments LUBAC functions, as is the case with loss of HOIL-1L ligase activity (17).