SLE susceptibility SNPs in TNIP1/ABIN1 augment linear ubiquitination by reducing expression of ABIN1 (9, 26, 27, 50, 51); this is because ABIN1 suppresses LUBAC functions acting as a linear chain-specific autophagy adaptor (13). The gene discussed is TNIP1; the disease is systemic lupus erythematosus.