We also sought to identify RBCK1/HOIL-1L SNPs/SNVs that attenuate HOIL-1L ligase activity and found that the RBCK1/HOIL-1L SNV (rs774507518) encoding HOIL-1L R464H showed significant enrichment in SLE (Table 1). Here, RBCK1 is linked to systemic lupus erythematosus.