Next, we examined the reported RBCK1/HOIL-1L SNPs/SNVs in the context of the 2 criteria and found that among the reported RBCK1 SNPs/SNVs in the RBR region, only 2 (rs1208529314 and rs774507518) appeared to be suitable candidates as causative agents of SLE (Supplemental Figure 6A). Here, RBCK1 is linked to systemic lupus erythematosus.