IFNA1 and inflammatory bowel disease: To explore if any of the predicted lncRNAs identified in our analysis regulate an inflammatory pathogenesis seen in IBD, we focused our attention on the brown4 module, which was enriched for an IFN response signature, correlated with inflammation and disease severity, and enriched for IBD GWAS SNPs (Figure 4, C and D; Figure 6, A and B; and Figure 8A).