Tumor growth, the number of tumor-infiltrating CD8+ T cells (Supplemental Figure 5, B and C), and the subsets of CD8+ T cells were comparable between mice that received WT T cells and those that received Sema6D-KO T cells (Supplemental Figure 5D), suggesting that Sema6D expressed by T cells is not involved in the immunosuppressive mechanism. This evidence concerns the gene SEMA6D and neoplasm.