CD8A and head and neck squamous cell carcinoma: Finally, we evaluated TCGA data sets of HNSCC and pan-cancer patients using Cbioportal (https://www.cbioportal.org/), and found that SEMA6D expression negatively correlated with CD8A, PDCD1, IFNG, and GZMB expression, suggesting that the findings in mouse models can be applied to human patients with cancer.