SEMA6D and cancer: To investigate the role of Sema6D in human cancer, we used Cbioportal (https://www.cbioportal.org/) to analyze public data sets of bulk RNA sequences from an HNSCC cohort (The Cancer Genome Atlas [TCGA], Firehose Legacy) and a pan-cancer cohort (International Cancer Genome Consortium [ICGC]/TCGA, Nature 2020) (23).