Finally, we evaluated TCGA data sets of HNSCC and pan-cancer patients using Cbioportal (https://www.cbioportal.org/), and found that SEMA6D expression negatively correlated with CD8A, PDCD1, IFNG, and GZMB expression, suggesting that the findings in mouse models can be applied to human patients with cancer. Here, PDCD1 is linked to head and neck squamous cell carcinoma.