Tumor progression was significantly reduced and CD8+ cell tumor infiltration was significantly increased in Sema6d-KO mice reconstituted with WT or Sema6d-KO bone marrow cells (WT→Sema6d-KO and Sema6d-KO→Sema6d-KO) compared with WT mice reconstituted with WT or Sema6d-KO bone marrow cells (WT→WT and Sema6d-KO→WT) (Figure 3, D and E). Here, CD8A is linked to neoplasm.