SLC40A1 and heart disorder: Furthermore, oral ferroportin inhibitors (e.g., vamifeport and substituted benzoimidazole compounds) can relieve ineffective erythropoiesis and improve body iron parameters in iron overload−associated TDT mice, as well as treat patients suffering from neurodegenerative and cardiac diseases (Kadam et al., 2021; Kalleda et al., 2023).