In immature T-ALL cases, transcription factors controlling early hematopoiesis, including MEF2C, TP63, HHEX, RUNX2, HOXA10, HOXA9, RUNX1T1, and ZBTB16; homeobox genes including HOPX, LYL1, LMO2, and LYN (a tyrosine kinase–coding gene) were highly expressed. Here, ZBTB16 is linked to acute lymphoblastic leukemia.