We found a significant association between immature T-ALL immunophenotype with high expression of BAALC (P = 0.001), MEF2C (P = 0.002), LYL1 (0.018), and HHEX (P = 0.007); and low expression of EZH2 (P = 0.005). This evidence concerns the gene HHEX and acute lymphoblastic leukemia.