In good accordance with our previous reports (26, 27, 29), at 8 months postinjury, the existing rmTBI model induced significant long-term neurological and cognitive deficits (Fig. S1C and D) accompanied by cortical progressive degeneration of white matter (WM; Fig. S1E and F), axonal pathology (Fig. S2A), and tau pathology (Figs. S2B, S2C, and S3A–F). This evidence concerns the gene MAPT and Cognitive impairment.