CERS1 and neurodegenerative disease: Together, our current results support the idea that p17 drives mitochondrial CerS1 trafficking to induce C18-Cer–mediated mitophagy, thus ensuring mitochondrial quality control by maintaining a healthy pool of axonal mitochondria in the brain (Fig. 6), which, in turn, may contribute to a susceptibility to developing progressive neurodegenerative diseases post-rmTBI, including CTE.