The mode of action of beta-blockers remains unclear, but vasoconstriction, down-regulation of angiogenic factors such as VEGF and bFGF and up-regulation of apoptosis of capillary endothelial cells may be responsible for the inhibition of growth, thus promoting regression of superficial IH.12,13 In this study, we found a significant response of treatment in 93.4% of lesions within four months of initiating topical timolol gel treatment. Here, VEGFA is linked to isolated hemihyperplasia.