Notably, SARS-CoV-2 anti-Spike antibody titer pre-PrEP was lower in COVID-19 patients (n = 46) compared to non-infected patients (n = 218): 3.1 (3.0–49.8) vs. 18.5 (3.0–98.3) BAU/mL (p = 0.039). This evidence concerns the gene CHMP5 and COVID-19.