The N protein of SARS-CoV-2 has been found to interact with several RNA helicases, including DDX1, DDX3, DDX5, DDX6, DDX21, and DDX10; among them, DDX1, DDX5, and DDX6 are essential for virus replication, while DDX21 and DDX10 restrict the viral infection (Ariumi, 2022). The gene discussed is DDX21; the disease is viral infectious disease.