Following digital analysis, we divided the patient cohort according to median expression in tumor stroma (FAP: n = 106 low, n = 105 high; PDGFRb: n = 106 low, n = 106 high; periostin: n = 106 low, n = 105 high; α-SMA: n = 107 low, n = 106 high) (Table 2). Here, ACTA1 is linked to neoplasm.