Furthermore, cleavage stimulation factor subunit 2 (CSTF2) has been found to assist in alternative polyadenylation-induced shortening of the 3′UTR of HuR mRNA, which is essential for increased HuR translation in tamoxifen-resistant (TAMR) estrogen receptor-positive breast cancer (Tan et al., 2017). This evidence concerns the gene ELAVL1 and breast cancer.