ZBTB18 and schizophrenia: We also detected significant regions, which were cis-regulatory elements (CREs): chr1:244164789 (a promoter flanking region), which is located near ZBTB18 and ADSS; ZBTB18, which encodes a DNA-binding transcription factor coordinating neurodevelopment during the formation of the mammalian cerebral cortex (69); ADSS (a catalyst in the early stages of adenosine monophosphate synthesis), the overexpression of which has been implicated in schizophrenia, suggesting that it plays an important role in the development of this condition.