CDK4 and cancer: In a similar study, seven proteins (AIF-1, ALP2, B-FABP, CDK4, ICA69, NCK- 1, and PRSS1) were upregulated in cancer samples, of which differential expression of B-FABP, CDK4, and NCK-1 was also validated by WB and IHC, and these could be used as potential cervical cancer markers (44).