Some reports suggest a crucial role for Tconv in tumor clearance (Perez-Diez et al., 2007; Kreiter et al., 2015), while others propose that they are dispensable (Zamarin et al., 2017), which might be due to their ability to aide in robust activation of CD8+ T cells, macrophages, and NK cells (Shedlock and Shen, 2003; Bevan, 2004; Williams et al., 2006; Livingstone et al., 2009). The gene discussed is CD8A; the disease is neoplasm.