Additionally, CD46 is expressed in endothelial cells and glial cells in the human brain, and it could mediate inflammatory response and phagocytic activity, promoting the microglial Aβ clearance, while dysfunction of these processes might contribute to the accumulation of Aβ and neuroinflammation in the pathogenesis of AD (Salminen et al., 2013). Here, CD46 is linked to Alzheimer disease.