A total of 12 genes related to the AD pathway were highly expressed in the endothelial cells and pericytes, which included APP, COX7A1, UQCRQ, ATP5PF, NDUFA8, NDUFB4, NDUFB6, COX6C, COX5B, BAD, COX7A2, and NDUFC1 (Figure 4B). The gene discussed is COX5B; the disease is Alzheimer disease.