In addition, strong A4B1 interactions with FN1, VCAM1 and other ligands (Baiula et al., 2019) are seen with fibroblasts in P5-1, P6-1, and P7-1 (Supplementary Figure S5A), and ESC in P6-1 (Supplementary Figure S5B); A4B1 receptors have been proposed to target therapy in inflammatory disorders and cancer (Baiula et al., 2019). The gene discussed is FN1; the disease is cancer.