More recently, in tuft cell-like SCLC cells, the coactivators of POU2F3 (POU2AF2 and POU2AF3) were found to endow POU2F3 with a critical transactivation domain by forming a master regulator complex, which supports enhancer-mediated cancer-promoting gene activation in SCLC-P cells14–16. The gene discussed is POU2F3; the disease is cancer.