Concurrent with the loss of chromatin accessibility, chromatin immunoprecipitation followed by sequencing (ChIP-seq) showed diminished chromatin binding of POU2F3 and its coactivators (POU2AF2, POU2AF3) at the AU-15330-mediated compacted sites, as examined by tagging endogenous or exogenous POU2F3 and its coactivators in SCLC-P cell lines (Fig. 2C, Fig. S3A–F). This evidence concerns the gene POU2AF3 and small cell lung carcinoma.