POU2F3 and small cell lung carcinoma: Real-time quantitative reverse transcription PCR (qRT-PCR) and global transcriptomic profiling via RNA sequencing (RNA-seq) showcased significant downregulation of POU2F3, POU2AF2/3, and their downstream targets (e.g., PTGS1) in multiple SCLC-P cell lines (Fig. 2E–F).