TMEM106B and amyotrophic lateral sclerosis: We also analyzed the TMEM106B 3’UTR in a series of 83 frontal cortex brain samples from the Mayo Clinic Brain Bank using qRT-PCR and found a significant increase in longer TMEM106B 3’ UTRs in the frontal cortices of patients with FTLD-TDP compared with healthy controls (Fig. 3f), indicating that the increased 3’ UTR length of TMEM106B might be functionally relevant in FTD/ALS.