TDP-43 knockdown caused widespread APA changes (Fig. 1e; Table S2; |ΔPUI| > 0.1 and adjusted p value < 0.05 from APAlyzer), including 24 changes also observed in FTD/ALS postmortem brain samples (Fig. 1b, S1a). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.