To test the hypothesis that APA caused by TDP-43 dysfunction contributes to FTD/ALS, we first performed APA analysis in an RNA-seq dataset26, in which neuronal nuclei with and without TDP-43 were sorted from FTD/ALS postmortem brain samples for RNA-seq (Fig. 1a, top panel). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.