Ubiquitination and phosphorylation are two commonly found pathological hallmarks of TDP-43 inclusions in ALS and FTD patients.15,50,51 HSPB1, a small heat shock protein which was shown previously to interact with misfolded TDP-43,46 weakly localized to stress granules before intra-condensate demixing (Figure 1E). This evidence concerns the gene HSPB1 and frontotemporal dementia.