TARDBP and amyotrophic lateral sclerosis: Human genetics suggests a strong connection between ALS and a type of biomolecular condensate called a stress granule.29–33 Stress granules are canonical condensates in the eukaryotic cytosol that are triggered by various stresses and assemble via interactions between RNA and RNA-binding proteins.34–36 Because many of these stress granule-associated RNA-binding proteins have been linked to ALS, it has been hypothesized that stress granules could in part be crucibles of such diseases.31 However, the role of cellular condensates in promoting aggregation of TDP-43 is controversial.