IGHE and allergic disease: For any allergy (medically diagnosed IgE mediated and/or parental report), no clear differences were seen in children either at 12–36 months (RR: 0.89 [0.71 to 1.11]; two RCTs, 823 children) or beyond 36 months of age (RR: 0.96 [0.84 to 1.09]; three RCTs, 1,765 children).