Interleukin-6 (IL-6) is a cytokine that plays a role in inflammation and has cardiovascular effects as it regulates hypertrophy and apoptosis of cardiomyocytes [2]. An increase in cardiac IL-6 expression was observed in advanced HF, which indicates its role in prognosis [2]. Increased levels of IL-6 are linked to left ventricular dysfunction before diagnosis of HF, indicating its role as a risk marker for the initiation and progression of HF [2]. This evidence concerns the gene IL6 and hydrops fetalis.