It is the primary apolipoprotein of chylomicrons, very low-density lipoprotein (VLDL), intermediate-density lipoprotein, and low-density lipoprotein (LDL) particles [27]. apo B-100 is a hepatic-derived lipoprotein that is used in the measurement of LDL particle concentration [27]. High levels of apo B indicate a higher risk of CVD even when LDL-C or non-HDL-C levels are low, especially in individuals with metabolic syndrome and type 2 diabetes [27]. This evidence concerns the gene APOB and type 2 diabetes mellitus.