NRP1 and congestive heart failure: ST2 belongs to the interleukin-1 receptor family and manifests in two distinct forms: a transmembrane receptor known as ST2L, and a soluble decoy receptor referred to as ST2. Studies have shown that individuals diagnosed with acute myocardial infarction, acute heart failure, and chronic heart failure have shown correlations between increased plasma sST2 concentrations and a raised likelihood of mortality and nonfatal adverse cardiac events [10].