NRG1 and coronary artery disorder: NRG-1 is a paracrine growth factor that is released from endothelial cells and binds to a family of erythroblastic oncogene B (ErbB) receptors on nearby cardiac myocytes to promote cell survival, growth, and maintenance [10]. Research has demonstrated a correlation between increased levels of NRG-1, and HF, and CAD [10].