ACVR2A and pulmonary hypertension: PubMed, Google Scholar, and Clinicaltrials.gov were searched from inception to June 8, 2023, using the keywords and MeSH terms: "Sotatercept," "ACE-011," "ActRIIA-IgG1," "ACTRIIA-Fc," "MK-7962," "RAP-011," "ActRIIA-IgG1Fc," "Activin receptor type IIA antagonist," and "Pulmonary hypertension." Studies were selected if they were (1) RCTs and (2) included patients with PAH randomized between Sotatercept and placebo.