We computed standard mean difference (SMD) and 95% confidence interval (CI) regarding the comparison of blood nesfatin-1 in patients with PCOS and controls.<h4>Results</h4>The present meta-analysis showed no significant difference in blood nesfatin-1 level between patients with PCOS and controls with a random effects model (SMD = 0.03; 95%CI: -0.71, 0.77; I<sup>2 =</sup> 97.1%, <i>p</i> value for Q test < 0.001). Here, NUCB2 is linked to polycystic ovary syndrome.