AAV-mediated gene overexpression of NT-3, glial cell line-derived neurotrophic factor (GDNF), and activity-dependent neurotrophic factor 9 (ADNF-9) in animal cochlea has shown a protective effect against aminoglycoside-induced HL, mitigating cell damage (Yao et al., 2007; Liu et al., 2008; Zheng et al., 2013). This evidence concerns the gene GDNF and Hodgkins lymphoma.