Although our previous study has revealed that dorsal horn DHX9 regulated the production of ciRNA-Fmn1 by binding to DNA-tandem repeats and contributed to the genesis of neuropathic pain,47 the specific regulatory mechanism underlying the role of DHX9 in hippocampal synaptic plasticity in the context of neuropathic pain is elusive. This evidence concerns the gene FMN1 and neuropathic pain.