Although our previous study has revealed that dorsal horn DHX9 regulated the production of ciRNA-Fmn1 by binding to DNA-tandem repeats and contributed to the genesis of neuropathic pain,47 the specific regulatory mechanism underlying the role of DHX9 in hippocampal synaptic plasticity in the context of neuropathic pain is elusive. The gene discussed is DHX9; the disease is neuropathic pain.