,18,19,20,21 A recent study demonstrated that eIF4AIII, an SF2 helicase, modulates synaptic strength and neuronal protein expression by mediating cytoplasmic mRNA metabolism via a host of trans-acting factors that, together with the mRNA, form a messenger ribonucleoprotein particle (mRNP)22 that may participate in the pathophysiology of psychiatric and neurological diseases, including neuropathic pain. The gene discussed is SRSF1; the disease is nervous system disorder.