To address the above-mentioned key knowledge gaps, we collected nearly 25 transcriptomic datasets, including the apolipoprotein E deficient (ApoE–/–) angiotensin II (Ang II)-induced abdominal aortic aneurysm (AAA) mouse model (10, 69), the ApoE–/– atherosclerotic aorta in high fat diet (HFD) feeding for three time points, including 6 weeks, 32 weeks, and 78 weeks, the ApoE–/– Ang II-induced AAA examined on three time points, including 7 days, 14 days, and 28 days, and VSMCs stimulated by various DAMPs. This evidence concerns the gene APOE and abdominal aortic aneurysm.