Therefore, we examined 15 pioneer TFs (83) and found that one (ASCL1) and two (CEBPA and GATA) pioneer TFs were upregulated in ApoE–/– at 6 weeks and 78 weeks, respectively; one (SOX2) pioneer TFs was upregulated in PPE-AAA; and one (GATA) and one (FOXA) pioneer TFs were upregulated in ApoE–/– Ang II-AAA at 7 days and 14 days, indicating that five pioneer TFs, including ASCL1, CEBPA, GATA, SOX2, and FOXA, play significant role in aortic diseases (Figure 5E). Here, SOX2 is linked to triple-A syndrome.