Venn diagram analysis of ApoE–/–HFD time course in Figure 3C showed upregulation of 17 cytokines and chemokines in ApoE–/– at 6 weeks, representing the first wave cytokines and chemokines, 19 atherosclerosis-specific cytokines and chemokines at 32 weeks, 102 second wave cytokines and chemokines were shared between 32 and 78 weeks; however, 78 weeks showed 106 atherosclerosis-specific cytokines and chemokines. Here, APOE is linked to atherosclerosis.