We reported that the secretomic signaling pathways in ApoE–/– atherosclerosis at 6 weeks, 32 weeks and 78 weeks (78) are different; and the secretomic signaling pathways in ApoE–/– Ang II at 7 days, 14 days and 28 days (79) are also different (22); and Treg-derived anti-inflammatory/immunosuppressive cytokine IL-35 inhibits inflammatory genes at the early phase and promotes tissue repair at the late phase of hind-limb ischemia (139). The gene discussed is AGT; the disease is atherosclerosis.