TGFB1 and Marfan syndrome: In addition, innate immune genes were upregulated in human VSMCs stimulated by metabolic DAMP (86, 87) homocysteine (Hcy) (10 μM), Hcy (100 μM), Hcy (100 μM) versus Hcy (10 μM) (87–89), proinflammatory cytokine IL-17 (49, 50), anti-inflammatory (90, 91), Treg-inducing (21), aneurysm-suppressing (92) and VSMC senescence/Marfan syndrome-inducing (93) cytokine TGF-β (1 ng/ml), and TGF-β (5 ng/ml), respectively.