Atherosclerosis was associated with upregulation of oxidative, necrotic, and pyroptotic cell death genes and efferocytosis genes; PPE-AAA upregulated more cell death genes than that of other AAA models; ApoE–/– Ang II-AAA at 7 days and 28 days upregulated more cell death genes than that of 14 days; and cholesterol loading upregulated more oxidative death genes in VSMCs, whereas LPS induced more necrotic death genes in VSMCs. This evidence concerns the gene APOE and atherosclerosis.