IgD+%B cell (p-value=0.0066; B cell panel), CD20-CD38-%B cell (p-value=0.0457; B cell panel), CD11c+ HLA DR++ monocyte %monocyte (p-value=0.0127; cDC panel), CD28- CD25++ CD8br %T cell (p-value=0.0339; Treg panel), Activated & resting Treg AC (p-value=0.0018; Treg panel), and T/B (p-value=0.0223; TBNK panel), DP (CD4+CD8+) %leukocyte (p-value=0.0087; TBNK panel), HLA DR+ CD8br AC (p-value=0.0386; TBNK panel), CD45 on CD4+ (p-value=0.0335; TBNK panel) had a positive correlation effect on the risk of breast cancer. This evidence concerns the gene CD4 and breast cancer.