BAFF-R on IgD+ CD38- unsw mem (B cell panel; Odds ratio:0.9819, 95%CI:0.9731-0.9908, p-value:6.93×10−5) and CD27 on PB/PC (B cell panel; Odds ratio:0.7162, 95%CI:0.7162-0.8093, p-value:2.72×10−18) were both linked to a decreased risk of breast cancer according to the IVW method, and these findings were consistent with the results from the weighted mode and weighted median. This evidence concerns the gene CD27 and breast cancer.